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SECOND PAPER: THE ACID FIXING POWER OF THE BLOOD IN RENAL DISEASE

JOHN B. RIEGER, M.D.; HUGO A. FREUND, M.D.

Arch Intern Med. 1922;30(4):517-530.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Our present conception of the physiologic acid-base equilibrium, resting largely on the work of L. J. Henderson,¹ assigns to the kidney the principal rôle in maintaining the normal alkalinity of the body fluids. So adequate is the healthy kidney in this respect that the production of acid within the body may be increased to many times the basal amount, as, for example, during great muscular exertion and in the ketosis of diabetes mellitus, without sensibly reducing the bicarbonate content of the blood.

Indeed, from the work of Straub and Schlayer,² Lewis and his co-workers,³ of Peabody,⁴ Whitney,⁵ MacNider,⁶ Gettler and St. George,⁷ Chace and Myers,⁸ and others, it appears that no appreciable reduction of the blood bicarbonate occurs, until the function of the kidney, as determined by the conventional tests, has been affected gravely. Acidosis, defined as a condition of lowered blood bicarbonate, appears, then, to be of little importance . . . [Full Text PDF of this Article]

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Footnotes
The first paper, "The Alkalimetry of Whole Blood—A Preliminary Study," by John B. Rieger, appeared in the J. Lab. & Clin. M. 5:668 (July) 1920.

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