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STUDIES IN ASYMPTOMATIC NEUROSYPHILISIII. THE APPARENT INFLUENCE OF PREGNANCY ON THE INCIDENCE OF NEUROSYPHILIS IN WOMEN
JOSEPH EARLE MOORE, M.D.
Arch Intern Med. 1922;30(5):548-554.
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In the second paper of this series1 it was pointed out that in spite of the fact that clinical neurosyphilis is more common in men than in women, cytobiologic abnormalities in the cerebrospinal fluid of primary and secondary syphilitics are equally frequent in the two sexes. Futhermore, evidence was presented to show that from the group of patients showing these early fluid abnormalities (early asymptomatic neurosyphilis) arise most, if not all, of the late cases of clinical meningeal and parenchymatous neurosyphilis. Since women are comparatively exempt from clinical neurosyphilis, there must be some special factor, applying only to the female sex, which inhibits its development. It was suggested that pregnancy might be the factor in question. The purpose of this paper is to examine this point more in detail.
The literature is replete with statistics, dating from the earliest days of the study of syphilis, regarding the comparative incidence of
. . . [Full Text PDF of this Article]
Author Affiliations
BALTIMORE
From the Syphilis Department of the Medical Clinic, Johns Hopkins Hospital.
Footnotes
This clinical research has been aided by grants from the United States Interdepartmental Social Hygiene Board and from the American Social Hygiene Association.
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