This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

C. A. L. BINGER, M.D.; A. B. HASTINGS, Ph.D.; J. M. NEILL, Ph.D.

Arch Intern Med. 1923;31(1):145-150.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sellards¹ showed that in normal persons the administration of from 5 to 10 gm. sodium bicarbonate is sufficient to turn urine alkaline, while in patients suffering from acidosis a greater amount is required. Indeed, Palmer reports patients suffering from uremia who received 112 gm. sodium bicarbonate and still excreted acid urine. Further investigations by Palmer and Van Slyke² demonstrated that in normal men the urine becomes more alkaline than the blood (pH = 7.4) when the plasma bicarbonate exceeds 71 ± 5 volumes per cent. Of the ten pathologic cases which they studied during sodium bicarbonate administration, most showed a higher plasma bicarbonate level than this, before the urine became more alkaline than the blood. They conclude, therefore, that in pathologic conditions there is danger of giving "unnecsary and perhaps injurious" amounts of sodium bicarbonate if administration is continued until the urine turns alkaline; and that the administration should be . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Hospital of the Rockefeller Institute for Medical Research.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?