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BRUCE C. LOCKWOOD, M.D.; HAZEN G. CHAMBERLIN, M.D.

Arch Intern Med. 1923;32(1):74-81.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The object of this work was to determine by fractional analysis, in a sufficiently large number of persons, two points: (1) whether or not alkalis in addition to their immediate neutralizing effect also produce a secondary rise of acidity greater than that which occurs in a person without their administration; (2) what effect alkalis have on gastric motility.

Without extensively quoting the early literature on the subject, it is sufficient to state that there has always been a difference of opinion as to whether alkalis act as a stimulant or depressant to gastric secretion. The defenders of the alkaline Spa treatments held that while at times an alkali might act as a stimulant shortly after taking, the prolonged administration caused a gastric catarrh with associated decreased secretion. Those who believed that alkalis acted only as a depressor of gastric secretion were supported by Pawlow's observation¹ that on a dog, soda . . . [Full Text PDF of this Article]

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