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II. RESULTS OF TREATMENT BY DIET ADJUSTMENT WITH REFERENCE TO MAINTENANCE REQUIREMENT AND THE KETOGENIC-ANTIKETOGENIC BALANCE

WILLIAM S. McCANN, M.D.; R. R. HANNON, M.D.; WILLIAM A. PERLZWEIG, Ph.D.; EDNA H. TOMPKINS, A.B.

Arch Intern Med. 1923;32(2):226-258.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

During the years 1921 and 1922 there were two highly important developments of knowledge which promise to be of epoch-making significance in the therapy of diabetes mellitus. The first of these is the regulation of ketogenesis. The second is the specific therapy by means of an extract of the pancreas discovered by Banting.¹

The problem of treatment of diabetes mellitus has long been in a highly unsatisfactory state. Faced with a disease, which he could not cure, the clinician sought to prolong life by the methods of starvation and undernutrition brought into vogue by Allen,² and endorsed by Joslin.³ Diets were frequently given which furnished adequate amounts of protein, but they were low in carbohydrate content, and generally contained relatively small amounts of fat because of the fear of inducing ketosis by excessive fat ingestion. It seemed generally to have been overlooked that the oxidation of fat continued during starvation . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

Footnotes
The Medical Clinic, Johns Hopkins Hospital.

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