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I. EFFECTS PRODUCED BY THE ADMINISTRATION OF MASSIVE DOSAGE TO PATIENTS WITH NORMAL MECHANISM

DREW LUTEN, M.D.

Arch Intern Med. 1924;33(2):251-278.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It has long been known that the administration of digitalis to patients with heart disease produces striking clinical improvement in many cases. Students of cardiology have long been occupied with two closely related problems: (a) a differentiation of those cases that are improved, from those that are not benefited by the drug; (b) an explanation of its action, and an understanding of the manner in which it produces improvement. Little progress was made toward a solution of these problems until recent years, and even now, although advancement has been rapid, no more than a fair beginning has been made.

A few facts have been established. It is well known that digitalis causes considerable delay in auriculoventricular conduction in many patients, and careful studies¹ have indicated that prolongation of a-v conduction of greater or less degree is a constant effect of the drug in all cases. The exact mechanism by which . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Department of Internal Medicine, Washington University School of Medicine.

Footnotes
Read before the Saint Louis Medical Society, May 22, 1923.

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