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THOMAS E. BUCKMAN, M.D.; GEORGE R. MINOT, M.D.; GENEVA A. DALAND, S.B.; MARGARET WELD

Arch Intern Med. 1924;34(2):181-190.

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Moraczewski,¹ in 1895, demonstrated abnormally low values for the total phosphorus content of the whole blood in certain cases of cancer and these findings suggested to Groebly² and others that diagnostic significance might be attached to the phosphorus content of the blood. Groebly has reported an increased total phosphorus content of the whole blood of patients suffering from cancer, and at the same time has recognized a relationship between it and the number of red corpuscles per unit volume of blood. To show this relationship he has made use of what he terms the "phosphorus quotient" represented by the expression, P/R, where P is the total phosphorus, as phosphorus pentoxid, in 10 c.c. of whole blood and R is the number of millions of red corpuscles in 1 c.mm. of blood. Groebly considers that in normal persons the phosphorus quotient ranges from 2.64 to 2.92 and that it has a . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

Footnotes
From the Medical Service of the Collis P. Huntington Memorial Hospital. This paper is No. 16 of a series of studies in metabolism from the Harvard Medical School and allied hospitals. The expenses of this investigation have been defrayed, in part, by a grant from the Proctor Fund of the Harvard Medical School for the study of chronic diseases.

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