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WILLIAM BLOOM, M.D.; WILLIAM H. ROSENAU, M.D.

Arch Intern Med. 1924;34(4):446-454.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Attempts to measure the functional powers of the liver by various tests have occupied a rather prominent position in recent medical literature. The phenoltetrachlorphthalein test during the last few years has given promise of being the most valuable of the various methods proposed. Abel and Rowntree,¹ in 1909, discovered that, except for traces which appeared in the urine, this dye was apparently eliminated only by the liver after subcutaneous or intravenous injection of the disodium salt. They also found that the substance was nontoxic to dogs, even when injected daily for several months in very large doses. They noticed, moreover, that subcutaneous injections of the dye had a prolonged laxative action. Several years later Rowntree, Hurwitz and Bloomfield,² Whipple, Mason and Peightal,³ and Whipple, Peightal and Clark⁴ undertook clinical and experimental investigations on the elimination of this dye by the liver and its applicability as a clinical test for liver . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Snydacker Fund and the Otto Baer Fund for Clinical Research of the Michael Reese Hospital and the Nelson Morris Memorial Institute for Medical Research.

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