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HERMAN E. PEARSE, A.B.

Arch Intern Med. 1925;35(3):347-356.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

INTRODUCTION

The pathology of Bichat, more than a century ago, centered about organs and tissues and that of Virchow about cells, while that of today also concerns the contents of later morphologic units. Little is known of the great variety of complex processes and of obscure changes which occur within cells, but it is recognized that the regulation of their hydrogen ion concentration plays an important rôle in maintaining their normal activity. In contrast to the simplicity of determining the hydrogen ion concentration of the body fluids, it is perhaps impossible to determine it accurately for a part or the whole of living cells. It is a frequent assumption that cells are of the same hydrogen ion concentration as their surrounding medium. That this is not necessarily the case has been shown by Bethe,¹ Warburg,² Harvey,³ and Jacobs⁴ from studies made on sea urchin eggs and plant cells. Jacobs has . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

Footnotes
From the medical service of the Collis P. Huntington Memorial Hospital of Harvard University. This paper is No. 37 of a series of studies on metabolism from the Medical School of Harvard University and allied hospitals. The expenses of this investigation have been defrayed by a grant from the Proctor Fund of the Medical School of Harvard University for the study of chronic diseases.

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