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THOMAS E. BUCKMAN, M.D.; GENEVA A. DALAND, S.B.; MARGARET WELD

Arch Intern Med. 1925;35(3):389-401.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

An abnormal phosphorus metabolism in leukemia has been recognized for over a quarter of a century, and yet very few observations are recorded in the literature relative to the phosphorus content of the blood in this type of disease. Moraczewski¹ in 1898 called leukemia, rather loosely, a "phosphorus and nitrogen disease" and reported not only an increased urinary excretion of phosphorus and nitrogen, but also an abnormally high phosphorus content of the blood. Though numerous studies since then, such as those of Musser and Edsall² and Knudson and Erdos,³ have clearly demonstrated the excessive output of phosphorus in the urine, there seems to be no report of any systematic investigations of the blood phosphorus in chronic myelogenous leukemia entailing an intensive study of cases over a considerable period of time. This is presumably due to the fact that it is but recently that relatively simple methods have become available for . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Medical Service of the Collis P. Huntington Memorial Hospital of Harvard University.

Footnotes
This paper is No. 35 of a series of studies in metabolism from the Harvard Medical School and allied hospitals. The expenses of this investigation have been defrayed (in part) by a grant from the Proctor Fund of the Harvard Medical School for the study of chronic diseases.

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