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THE MECHANISM OF PAIN IN GASTRIC AND DUODENAL ULCERSI. ACHLORHYDRIA
WALTER LINCOLN PALMER, M.D.
Arch Intern Med. 1926;38(5):603-611.
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INTRODUCTION
The genesis of pain arising from the stomach and intestine as the result of both functional and organic disorders has attracted much attention in recent years. Inflammation, muscle tension, acid irritation, edema, peritoneal irritation and perineural infiltration have all been ascribed their various rôles. The present work was undertaken with the hope that some aid might be obtained from a clearer understanding of the mechanism of pain in gastric and duodenal ulcers. It has naturally led into other fields at times, but attention has been focused chiefly on the benign peptic ulcer. One of the first problems encountered was that of the occurrence of ulcer and ulcer pain with achlorhydria.
LITERATURE
In the literature many allusions are found to ulcers with achlorhydria, but few of them are definite. For instance, in 1911, Gibson1 stated that the free acidity in his ulcer cases varied from 0 to 0.18 per cent.
. . . [Full Text PDF of this Article]
Author Affiliations
CHICAGO
From the Seymour Coman Fellowship in the Department of Physiology of the University of Chicago and the Cook County Hospital.
Footnotes
A dissertation submitted to the faculty of the Ogden Graduate School of Science in candidacy for the degree of doctor of philosophy.
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