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L. D. HUFFMAN, M.D.

Arch Intern Med. 1927;39(5):656-672.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Phenylhydrazine hydrochloride was used for the first time in the treatment of polycythemia vera in 1918 by Eppinger and Kloss.¹ They used the drug in four cases in which the number of erythrocytes was satisfactorily reduced, and the symptoms were relieved without apparent injurious effects on the patient. Others² on the continent have since reported their experiences. Owen³ was the first in this country to record experience with this method, and he has more recently⁴ amplified his previous report. Long,⁵ and Brown and Giffin⁶ have also attested its value.

So far as I know, quantitative metabolic studies have not been reported on patients with polycythemia vera during treatment with phenylhydrazine hydrochloride. Such studies not only should have academic interest, but should also furnish data by which the results of the treatment could be estimated.

The formula for phenylhydrazine is C₆H₅NH—NH₂. The drug and its compounds have been used extensively in . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN.

Footnotes
Abridgment of thesis submitted to the Factulty of the Graduate School of the University of Minnesota in partial fulfilment of the requirements for the degree of Master of Science in Medicine, 1926.

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