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A REPORT OF SIXTY-TWO CASES

T. L. ALTHAUSEN, M.D.; I. C. SCHUMACHER, M.D.

Arch Intern Med. 1927;40(6):851-872.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Ephedrine is an alkaloid that was isolated from the plant Ephedra vulgaris by Nagai in 1887 and rediscovered by Chen in 1923. Decoctions of Ephedra vulgaris have been used in China for five thousand years for diaphoretic and antipyretic purposes and as a sedative in cough. At the time of the original discovery of the alkaloid, the attention of the investigators was focused mainly on its mydriatic properties. To Chen¹ belongs the honor of working out the complete pharmacology of ephedrine, which was found to be a sympathomimetic drug closely allied in its chemical constitution and physiologic action to epinephrine. Chemically, ephedrine differs from epinephrine in that it does not contain a phenolic hydroxyl group, but has an extra methyl radical which accounts for its more persistent effects and greater stability, permitting oral administration of the drug and sterilization of its solutions by boiling. The physiologic effects of ephedrine are . . . [Full Text PDF of this Article]

Author Affiliations
SAN FRANCISCO

From the Department of Medicine, University of California Medical School.

Footnotes
Read before the Annual Meeting of the California State Medical Association in Los Angeles, April 25, 1927.

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