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ITS DEMONSTRATION IN A PATIENT WITH ACROMEGALY

HELMUTH ULRICH, M.D.

Arch Intern Med. 1928;41(6):875-882.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The pituitary body has for a long time been known to play a part in the mechanism that controls carbohydrate metabolism. Goetsch, Cushing and Jacobson¹ noted the high carbohydrate tolerance that accompanies pituitary deficiency, and they confirmed Borchardt's² previous assertion that the injection of pituitary extract caused hyperglycemia.

Stenström³ made the apparently conflicting observation that pituitary extract inhibited the hyperglycemia and glycosuria caused by injections of epinephrine hydrochloride. This was afterward confirmed by Burn⁴ who was led thereby to speculate that pituitary extract should enhance the action of insulin. He found the opposite to be true,⁵ namely, that posterior lobe extract, when injected into rabbits simultaneously with insulin, "had a powerful antagonistic effect on the action of insulin" as well as on that of epinephrine hydrochloride.

Olmstead and Logan,⁶ in their work with decerebrated cats, reached the same conclusion, and the studies of Joachimoglu and Metz,⁷ Laura,⁸ and others added . . . [Full Text PDF of this Article]

Author Affiliations
Associate Professor of Clinical Pathology, Boston University School of Medicine BOSTON

From the Evans Memorial for Clinical Research and Preventive Medicine.

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