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ISRAEL BRAM, M.D.

Arch Intern Med. 1928;42(1):53-55.

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About a decade ago, I began making observations on patients with exophthalmic goiter to determine their degree of tolerance to the ingestion of quinine. Part of the deductions derived were published in the nature of a description of the quinine test¹ for patients with exophthalmic goiter. Up to December, 1927, tolerance for quinine was studied in 500 patients. Following my preliminary reports, others made similar observations. Among those, Sainton and Schulman² arrived at negative conclusions, but their data were based on only ten cases. Pfahler,³ on the other hand, found the quinine test extremely useful.

THE QUININE TEST AND RESULTS OF USE OF THIS DRUG

The technic of the test consists in giving the patient a dozen capsules each containing 10 grains (0.65 Gm.) of quinine hydrobromide or quinine sulphate, with instructions to take a capsule four times a day. When 20 or 30 grains (1.3 or 1.9 Gm.) have . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

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