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REPORT OF A CASE, WITH STUDIES OF THE COPPER CONTENT OF THE LIVER

ELMER H. FUNK, M.D.; HUSTON ST. CLAIR, M.D.

Arch Intern Med. 1930;45(1):37-45.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1889, von Recklinghausen described a form of pigmentation affecting many organs of the body which he called hemochromatosis. This condition is often accompanied in its terminal stages by diabetes— the bronze diabetes of French writers. While the number of recorded cases (approximately a few over 100) would indicate that the condition is rare, various observers have pointed out that it may easily be overlooked clinically in the early stages when the skin pigmentation, glycosuria and the hemosiderin granules in the urine are absent. Mills¹ reported that in seventeen pathologically advanced cases, only two were recognized during life and proved positive by the demonstration of hemosiderin in an excised piece of skin. Many patients, no doubt, die of intercurrent diseases before the positive clinical picture of hemochromatosis is established. Excellent pathologic and clinical studies are recorded in the literature. The characteristic pathologic picture is the presence of hemofuscin and hemosiderin . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Medical Service of Dr. Thomas McCrae and the Ayer Clinical Laboratory of the Pennsylvania Hospital.

Footnotes
Submitted for publication, July 10, 1929.

Read before the Association of American Physicians, Atlantic City, N. J., May 7, 1929.

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