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LAY MARTIN, M.D.

Arch Intern Med. 1930;45(4):535-537.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In an article published about a year and a half ago, Dr. Anthony Bassler¹ made the following statements:

1. All proteolytic enzymes are dual in their action of conversion. This is true of the one in the stomach as well as of that in the pancreatic juice, both of which require outside activation, that of the stomach from hydrochloric acid and that of the pancreas from a product of the duodenal mucosa (enterokinase).

By this I judge he meant that some other agent is necessary to activate these enzymes. Certainly he cites hydrochloric acid as being necessary to activate pepsin. As this may cause misunderstanding, let me say that what pepsin needs for activation is a medium in which the hydrogen ion concentration is within certain limits. The same factor is necessary for trypsin. Therefore, no more than diastase and lipase are they dual in their action of conversion.

He . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Gastro-Intestinal Clinic of the Johns Hopkins Hospital.

Footnotes
Submitted for publication, Aug. 26, 1929.

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