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EFFECT OF NORMAL AND OF DIABETIC BLOOD ON INSULIN ACTION

SAMUEL KARELITZ, M.D.; PHILIP COHEN, M.D.; SIDNEY D. LEADER, M.D.

Arch Intern Med. 1930;45(4):546-558.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Patients suffering from diabetes mellitus are known to have periods during which they do not respond properly to insulin. It is likewise well established that diabetes becomes worse during infection, injury or operation. These observations have aroused much interest and investigation in the past few years. It is interesting that seventy-five years ago Claude Bernard¹ was well aware of the danger of infection to diabetic patients.

Patients who temporarily or permanently resist insulin action are called insulin resistant or insulin refractory. The periods of resistance to insulin may be recurrent, ending in spontaneous recovery, or may be lasting, terminating in coma and death.

In July, 1925, E. K., a girl, aged 6 years, with severe diabetes, began to have peculiar reactions to insulin. On a constant diet and without any evident complication, she seemed to resist insulin action at one time and at another to have hypoglycemia on the same . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Departments of Pediatrics and Laboratories of Mount Sinai Hospital.

Footnotes
Submitted for publication, Sept. 12, 1929.

A preliminary report of this study was published in Proc. Soc. Exper. Biol. & Med. 26:11, 1928.

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