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LEWIS GUNTHER, M.D.; DAVID M. GREENBERG, Ph.D.

Arch Intern Med. 1930;46(1):67-71.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Several workers have suggested that abnormalities in calcium metabolism may be significant in the genesis and development of neoplasms in man and in other animals. Thus Clowes and Frisbie¹ found calcium to be markedly low and potassium high in actively growing malignant tissue. Goldzieher² and Theis and Benedict³ reported low values for the total serum calcium in patients afflicted with carcinoma and other malignant tumors. Reymond, Sendrail and Lassalle⁴ and Sendrail⁵ claimed that a lowering of the serum calcium occurred in the precancerous phase of animals with experimentally induced neoplasms. Finally, McDonald⁶ went so far as to state that cancer is a disease associated with a lessened amount of total and ionized calcium in the blood. These observations led us to investigate the calcium fractions, the proteins and the inorganic phosphate of the blood serum in fifteen patients suffering from malignant diseases.

Recent work in the field of calcium metabolism⁷ . . . [Full Text PDF of this Article]

Author Affiliations
LOS ANGELES; BERKELEY, CALIF. With the Technical Assistance of John B. Dalton

From the Department of Medicine, San Francisco, and the Division of Biochemistry, University of California Medical School, Berkeley.

Footnotes
Submitted for publication, Nov. 30, 1929.

This research is one of a series carried out jointly in the Department of Medicine and the Division of Biochemistry of the University of California Medical School, with the cooperation of Professors W. J. Kerr and Carl L. A. Schmidt.

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