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EXPERIMENTS ON THEIR MATURATION

CLARK W. HEATH, M.D.; GENEVA A. DALAND, B.S.

Arch Intern Med. 1930;46(3):533-551.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The life history of red blood corpuscles has fascinated many investigators. A large amount of literature has accumulated regarding the development of red blood corpuscles, one phase of which concerns cells containing basophilic substance or, when supravitally stained, reticular substance and commonly known as reticulocytes. Since Theobald Smith¹ first suggested that these were young cells rather than degenerative forms of the adult red blood cell, an abundant amount of evidence has been presented which indicates clearly that the basophilic substance is a sign of youthfulness.

Some of the evidence that reticulocytes are less mature than nonbasophilic erythrocytes is well founded on multiple observations in states of anemia in which an increase of reticulocytes in the peripheral circulation precedes an increase in nonreticulated erythrocytes. Nevertheless, little information is available concerning the fate of such young cells: the duration of their stay in the circulation, the disposal of the basophilic substance and . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Thorndike Memorial Laboratory of the Boston City Hospital and the Department of Medicine of the Harvard Medical School.

Footnotes
Submitted for publication, Feb. 1, 1930.

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