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AN IMPROVED INDIRECT METHOD FOR THEIR ENUMERATION

ISADORE OLEF, M.D.

Arch Intern Med. 1930;46(4):585-596.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Numerous methods for counting blood platelets have appeared since Schultze's¹ original description in 1865 of these "granular formations" as microscopic cellular constituents of normal blood. Hittmair² in his recent review of the literature referred to twenty new methods that had appeared within the previous ten years. That these methods are for the most part unsatisfactory is indicated by the wide range of supposedly normal figures reported, as shown in table 1.

These wide differences may be explained by improper technic, which involves two kinds of errors: (1) loss or destruction of blood platelets and (2) the inclusion in preparations of artefacts and foreign matter which are mistaken for platelets. The first results in counts too low, the second in counts too high. The difficulties encountered by various investigators are undoubtedly due to the peculiar physical characteristics of the platelets; viz., their great tendency to agglutination, adhesion and easy disintegration, which . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Medical Clinic of the Boston Dispensary, Service of Dr. Joseph H. Pratt, and the Division of Research.

Footnotes
Submitted for publication, Feb. 18, 1930.

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