This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

EDWIN E. ZIEGLER, M.D.

Arch Intern Med. 1930;46(4):644-656.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1900, Neufeld¹ discovered that pneumococci in suspension were dissolved by adding bile to them.

Since that time, others have shown that solutions of the bile salts, i. e., sodium glycocholate and sodium taurocholate acted in the same way, and that whole bile was not necessary. In fact, there is evidence that the cholate part of the molecule is really the active part causing the lysis. This is one of the classic tests for the identification of pneumococci.

It is interesting to watch Neufeld's phenomenon under the high power of the microscope. To obtain this, mix a drop of pneumococcus suspension and a drop of bile salt solution on a glass slide, placing a cover-slip glass on it. The pneumococci gradually dissolve, becoming smaller and smaller. They pass through the stage in which they exhibit the brownian movement, and finally disappear.

Bile-solubility was found by Schilling² and Neufeld¹ to be . . . [Full Text PDF of this Article]

Author Affiliations
NORTHPORT, N. Y.

From the U. S. Veterans' Hospital.

Footnotes
Submitted for publication, March 6, 1930.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?