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CONTRIBUTION TO THE PROBLEM OF ESSENTIAL HYPERTENSION

W. RAAB, M.D.

Arch Intern Med. 1931;47(5):727-758.

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In a previous paper¹ there was described a characteristic feature of essential (not nephritic) hypertension, namely, an increased sensitivity of the vasomotor centers to changes in alveolar carbon dioxide tension: abnormally high rises of blood pressure during the inhalation of carbon dioxide and an abnormal fall of blood pressure during the increased exhalation of carbon dioxide (hyperventilation; Tirala² and Rappaport³). There is a striking parallelism between the figures of alveolar carbon dioxide and of blood pressure during hyperventilation in hypertonic patients, while a fall of carbon dioxide to the same extent does not change the blood pressure of hyperventilating normal persons in any definite way (Collin, Densham and Wells,⁴ Schneider⁵). From this characteristically different behavior of normal and hypertonic persons the conclusion has been drawn that a pathologic hypersensitivity of the vasomotor centers (not only to abnormally high amounts of carbon dioxide but even to the normal carbon dioxide content . . . [Full Text PDF of this Article]

Author Affiliations
Rockefeller Research Fellow VIENNA, AUSTRIA

From the Department of Physiology, Harvard Medical School, Boston.

Footnotes
Submitted for publication, June 13, 1930.

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