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  Vol. 48 No. 1, JULY 1931 TABLE OF CONTENTS
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ACUTE TOXIC HEPATITIS (ACUTE YELLOW ATROPHY) DUE TO CINCHOPHEN

REPORT OF A CASE

K. K. SHERWOOD, M.D.; H. H. SHERWOOD, M.D.

Arch Intern Med. 1931;48(1):82-88.

Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Diagnosis in cases of painless jaundice is always an interesting problem. The two most common causes are, of course, catarrhal jaundice and carcinoma of the head of the pancreas. It so happened that last spring we had on our hospital service at one time three cases of jaundice, all of relatively rare etiology, namely, hepatic syphilis, hereditary hemolytic jaundice and cinchophen poisoning. In this paper we shall briefly review the literature and report the case of cinchophen poisoning.

Chemically, cinchophen is a ring compound containing nitrogen. This occurrence of nitrogen in its double benzene ring undoubtedly is the cause of the occasional development of toxic symptoms. Its therapeutic action is twofold:1 first, as a mobilizer of uric acid, it remarkably hastens the excretion of uric acid through the kidneys; and second, it is a distinct antipyretic. This latter effect is marked, since a moderate dose will reduce the temperature . . . [Full Text PDF of this Article]


Author Affiliations

REDMOND, WASH; KIRKLAND, WASH.

From the medical service of the Virginia Mason Hospital, Seattle.


Footnotes

Submitted for publication, Sept. 20, 1930.

Read before the King County Medical Society, Seattle, Nov. 10, 1930.



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