This Article  • References  • Full text PDF  • Correction  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

ELI MOSCHCOWITZ, M.D.

Arch Intern Med. 1931;48(2):171-186.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Achlorhydria is the most constant symptom of pernicious anemia. Indeed, the reported cases of pernicious anemia in which hydrochloric acid was present are so few that doubt has been raised as to their validity. In my experience I do not recall an instance in which achlorhydria was absent. Cases in which hydrochloric acid was present eventually proved to be diseases other than pernicious anemia. Therefore, achlorhydria may be regarded as the most decisive differential sign in establishing the diagnosis of pernicious anemia.

Following Hunter, until recently achlorhydria was regarded as secondary and consequent to gastro-intestinal sepsis of unknown origin. With more intensive study, it becomes evident that this view is untenable for the following reasons: 1. If achlorhydria were secondary, one should expect occasionally in the course of the development of anemia to witness the gradual diminution of hydrochloric acid from normal to subacidity and finally to achlorhydria. But such . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

Footnotes
Submitted for publication, Nov. 26, 1930.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?