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II. THE RATE OF DYE MIXING

S. GRAFF, B.S.; D. A. D'ESOPO, M.D.; A. J. B. TILLMAN, M.D.

Arch Intern Med. 1931;48(5 I):821-827.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the first paper¹ a method for the accurate evaluation of brilliant vital red in the plasma was described. If the measurement of the dye concentration is to serve as an index of the total plasma volume, the mixing of the injected dye with the plasma must be complete throughout the circulation before there is any appreciable loss of dye. Two problems, then, would naturally follow: (1) to determine the time required for complete mixing of dye and plasma and (2) to find the rate of loss from the blood stream. These problems can be studied by determining the dye concentration in a series of samples of plasma taken at frequent measured intervals after the injection of the dye. The present communication deals with this study.

Measured volumes of dye of known concentration were injected into the median basilic vein of one arm, and 10 cc. samples were periodically . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the departments of Biological Chemistry and of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons.

Footnotes
Submitted for publication, Feb. 20, 1931.

This work was aided by grants from the Chemical Foundation.

From a thesis submitted by S. Graff in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Columbia University.

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