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LEO H. CRIEP, M.D.

Arch Intern Med. 1931;48(6):1098-1109.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The present conception of anaphylaxis indicates that symptoms and death occur as the result of the mechanical irritation produced on the cells of the so-called shock organ by the interaction of antigen and antibody. This shock organ has been shown to differ with various animals. Thus, in the guinea-pig, it has been found to be the smooth muscle of the bronchi and bronchioles. A guinea-pig dying in anaphylactic shock presents a definite and characteristic group of symptoms, the most prominent of which is gasping for breath. The animal dies with its lungs in a state of maximal distention. These symptoms are due to a closure of the bronchi and bronchioles, so that while air may be taken into the lungs because the accessory muscles of respiration are brought into play, it cannot be forced out of the lungs. The guinea-pig, therefore, dies in acute asphyxia. In the rabbit, however, the . . . [Full Text PDF of this Article]

Author Affiliations
PITISBURGH

From the Departments of Physiology and Internal Medicine, the University of Pittsburgh.

Footnotes
Submitted for publication, Feb. 23, 1931.

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