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HUGH R. LEAVELL, M.D.; HAROLD L. AMOSS, M.D.

Arch Intern Med. 1931;48(6):1192-1197.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The endermic reaction for Brucella infection has been used for the most part as a confirmatory test. But Burnet¹ and others have reported positive cutaneous reactions in cases in which the blood serum showed no agglutination with Brucella and in which the blood cultures were negative.

Various antigens have been used in testing for cutaneous hypersensitiveness to Brucella and its products. These antigens may be classified roughly into two groups: (1) bacterial suspensions and (2) filtrates of broth cultures.

The use of the filtrate of a broth culture from twenty to thirty days old was described in 1922 by Burnet,² who called the substance "melitin." It has since been widely used, particularly in countries bordering on the Mediterranean, and the results have varied. Trenti³ in 1923 reported specific reactions in nine cases of undulant fever, with negative results in forty controls. Olmer and Massot,⁴ Debré, Marie . . . [Full Text PDF of this Article]

Author Affiliations
DURHAM, N. C.

From the Biological Division of the Medical Clinic of the Johns Hopkins University School of Medicine and Hospital.

Footnotes
Submitted for publication, Feb. 24, 1931.

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