This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

W. C. HUEPER, M.D.; MARY RUSSELL, M.S.

Arch Intern Med. 1932;49(1):113-122.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Investigations of Carrel and Elbeling¹ into the proliferative activity of blood leukocytes in tissue cultures have shown that homologous serum possesses a marked antiproliferative effect on polymorphonuclear leukocytes and lymphocytes. The first mentioned type of white blood cell disappears entirely from the culture in a few days, and the latter type in from one to two weeks. By a process of physiologic selectivity a pure culture of mononuclear cells remains, which can be kept alive for several months. Carrel and Ebeling concluded from this observation that homologous serum may possess a similar action in vivo, because the number of leukocytes would increase indefinitely if serum were not endowed with this property. They added that probably the increase of the growthinhibiting action of serum in the course of life determines a decrease in the activity of the white cells and modifies their secretions. They suggested, moreover, that possibly this is . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Cancer Research Laboratories, University of Pennsylvania, Graduate School of Medicine.

Footnotes
Submitted for publication, April 11, 1931.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?