This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

AN ATTEMPT TO PRODUCE TOXIC CIRRHOSIS OF THE LIVER IN RATS

HERBERT S. REICHLE, M.D.

Arch Intern Med. 1932;49(2):215-220.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a previous paper¹ two cases of toxic cirrhosis were described that were observed clinically and examined at autopsy in the Cleveland City Hospital. Reports of many cases have since then appeared in the literature; cinchophen and its allies may now be regarded as drugs of considerable potential toxicity. Nevertheless, it remains true that cinchophen is used extensively without any apparent ill effects. It is, therefore, of considerable importance that the mechanism of the drug's toxic action be explained.

EXPERIMENTS

Adult albino rats were used in these experiments. They were fed dried whole milk, whole wheat flour, calcium carbonate, sodium chloride (Sherman's diet B) and weekly additions of meat and greens. In many of the rats infections of the upper and lower respiratory tracts developed, such as purulent bronchitis, pneumonia with atelectasis and disease of the middle ear, which were found with equal frequency among the controls.

The lethal . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Institute of Pathology and the Department of Pediatrics, Western Reserve University.

Footnotes
Submitted for publication, June 22, 1931.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?