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WITH SPECIAL REFERENCE TO THE RESPONSES OF THE CARDIOVASCULAR SYSTEM

SOMA WEISS, M.D.; GEORGE P. ROBB, M.D.; LAURENCE B. ELLIS, M.D.

Arch Intern Med. 1932;49(3):360-396.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The concept that histamine plays a fundamental rôle in the chemical control of the circulation is suggested by a series of observations by Dale and Lewis and their associates.¹ It is, however, remarkable that the evidence concerning histamine as a vasodilator substance in the physiologic regulation of the circulation is still largely based on indirect evidence and analogical observations. Direct proof for this function of histamine in the animal body is so far not available, and while the value of parallel and "teleologic evidence" in establishing a physiologic concept is considerable, it is recognized that concepts based on indirect evidence may be open to fallacy and therefore cannot be considered as proved.

Burn and Dale and their associates² observed a fall in the arterial blood pressure in anesthetized carnivorous animals. Lewis and his associates³ presented evidence that the human skin, when subjected to various sorts of stimuli, . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard) of the Boston City Hospital, and the Department of Medicine of Harvard Medical School.

Footnotes
Submitted for publication, May 5, 1931.

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