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REPORT OF TEN CASES

PAUL J. FOUTS, M.D.; L. G. ZERFAS, M.D.

Arch Intern Med. 1932;50(1):27-36.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Castle and Taylor¹ have recently shown that maximal responses of reticulocytes were obtained in the treatment of patients with pernicious anemia, during relapse, when the amount of liver extract derived from 100 Gm. of liver was administered intravenously. The solution suitable for intravenous injection was prepared by dissolving approximately 4.5 Gm. of a commercial preparation of fraction G² (liver extract) in physiologic solution of sodium chloride after washing the extract in ether. The solution was then filtered or centrifugated, sterilized by boiling for five minutes and made so that 20 cc. contained the amount of material derived from 100 Gm. of whole liver.

In studying the nature of the active principle in liver, Cohn³ and West⁴ and their respective associates had previously prepared highly purified fractions of liver which were suitable for intravenous injection and which were found to be potent. The practical application of these . . . [Full Text PDF of this Article]

Author Affiliations
INDIANAPOLIS

From the Lilly Laboratory for Clinical Research, Indianapolis City Hospital, and the Department of Medicine. Indiana University.

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