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TOM DOUGLAS SPIES, M.D.

Arch Intern Med. 1932;50(3):443-449.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since the observation that certain substances acquire antirachitic properties following exposure to ultraviolet rays,¹ great interest has centered on the artificial production of vitamin D and on its relationship to the diseases concerned with calcium metabolism. Soon after the initial discoveries, it was established² by a series of brilliant investigations that the specific substance activated by irradiation was ergosterol. The efficacy of viosterol (irradiated ergosterol) in the treatment of rickets and osteomalacia was quickly established. In addition, workers³ studied the effects of this material on normal laboratory animals. They demonstrated that an elevation of the blood calcium occurred and that calcium was deposited in the arterial walls, especially the aorta, and in the muscle of the heart, the wall of the stomach, the lungs and the kidneys. In still other experiments⁴ it was shown that even more widespread calcification occurred, and that the animals frequently had . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Pathological Laboratory of the Boston City Hospital.

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