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BRONCHIAL DISINFECTION AND IMMUNIZATIONII. EFFECTS IN RABBITS OF INTRABRONCHIAL INJECTIONS OF VACCINES, BACTERIOPHAGE AND ANTIVIRUS
JOHN A. KOLMER, M.D.
Arch Intern Med. 1933;51(5):692-703.
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While bronchial disinfection by intrabronchial lavage with various chemotherapeutic agents would appear to be both possible and safe, as determined by experiments on rabbits, and worthy of clinical trial in the treatment of bronchiectasis and other types of chronic suppurative pneumonitis,1 the results of additional experiments summarized in this paper indicate that local immunization and disinfection of the bronchi by intrabronchial injections of vaccines, antivirus and bacteriophage may offer even greater therapeutic possibilities and prove worthy of clinical trial in the treatment of bronchiectasis and other types of pulmonary suppuration.
Undoubtedly subcutaneous and intracutaneous injections of properly prepared autogenous vaccines are sometimes of therapeutic value in certain cases of chronic bronchitis, especially those associated with allergic asthma, but vaccine therapy has generally failed to be of any particular value in the treatment of bronchiectasis.
It would appear that intrabronchial injections of vaccines and antivirus may open up a new and
. . . [Full Text PDF of this Article]
Author Affiliations
PHILADELPHIA
From the Research Institute of Cutaneous Medicine and the Laboratories of the Graduate School of Medicine of the University of Pennsylvania.
Footnotes
Aided by a grant from the Faculty Research Committee of the Board of Graduate Education and Research of the University of Pennsylvania.
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