This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

REPORT OF TWO CASES WITH HISTOLOGIC OBSERVATIONS

H. H. PERMAR, M.D.; H. D. GOEHRING, M.D.

Arch Intern Med. 1933;52(3):398-409.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Cinchophen, or atophan as it was originally named, was first introduced as a drug in 1908 by Nicolaier and Dorhn,¹ who were able, by its use experimentally in animals and in man, to increase definitely the endogenous formation and excretion of uric acid. Owing to its spectacular ability to relieve pain in certain arthritic conditions, it was soon widely used in all types of neuritic and arthritic distress. So universal has its use become that, at present, it is being employed freely by the laity without any medical supervision.

Chemically, cinchophen is 2-phenylquinoline-4-carboxylic acid. Although it is known to have a cholagogic effect in dogs, its mode of action has not yet been definitely determined. Brugsch and Horsters² expressed the belief that cinchophen owes its cholagogic effect to direct stimulation of the hepatic cells, and they were able experimentally to show an increase in the twenty-four hour total . . . [Full Text PDF of this Article]

Author Affiliations
PITTSBURGH

From the Department of Pathology, School of Medicine, University of Pittsburgh and the Pathological Laboratories, Mercy Hospital.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?