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V. FURTHER OBSERVATIONS ON THE NATURE OF THE CUMULATION OF DIGITALIS

HAROLD L. OTTO, M.D.; HARRY GOLD, M.D.; CHARLES R. MESSELOFF, M.D.

Arch Intern Med. 1933;52(5):725-738.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A study of the elimination of digitalis in man was published in 1929 by Gold and DeGraff.¹ The subjects were ambulatory patients with auricular fibrillation and moderate congestive heart failure. Slowing of the ventricular rate (depression of the auriculoventricular conduction) and the relief of the circulatory failure served as the criteria of the action of digitalis. It was found that during the first few weeks a fixed daily dose of digitalis produced progressive slowing of the ventricular rate, but that after this period the rate remained constant, although the same daily dose was continued without interruption for many weeks. A typical record obtained in the study is reproduced in chart 1. The facts were interpreted in the following manner: The progressive slowing of the ventricular rate in the first period was understood to indicate that the patient was not excreting completely each daily dose of 3 grains (0.2 Gm.), . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Pharmacology, Cornell University Medical College, and the Cardiac Clinics of the Beth Israel Hospital and the Hospital for Joint Diseases.

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