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CYRIL M. MacBRYDE, M.D.

Arch Intern Med. 1933;52(6):932-944.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

From the earliest days of the use of insulin in the treatment of diabetes mellitus there have been reports of cases in which larger doses were required than the clinical condition of the patient seemed to warant. Such cases were first described by Jaksch-Wartenhorst,¹ Mahler and Pasterny,² Umber and Rosenberg,³ Falta,⁴ Radoslav,⁵ Pollak,⁶ von Noorden and Isaac⁷ and Matthes.⁸ In the nine years since that time, numerous reports have revealed that in acidosis, in coma and in the presence of infection, hepatic disease or certain endocrine disorders the effectiveness of insulin may be decreased. Psychic disturbance and lack of exercise have been observed to raise the amount of insulin required. There are, however, many cases in which the poor response is unexplained. "Insulin resistance" as the term describing relative ineffectiveness of insulin is commonly used, although there is as yet no general agreement as to its definition. Joslin⁹ and . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

Fellow in Medicine, Kaiserin Elisabeth Spital, Vienna.; From the First Medical Division, Kaiserin Elisabeth Spital, Vienna; Director, Prof. Dr. Wilhelm Falta.

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