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AN EXPERIMENTAL STUDY

TOM D. SPIES, M.D.

Arch Intern Med. 1933;52(6):945-947.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Nearly two hundred years ago pellagra was described as a clinical syndrome related to poverty and inadequate nutrition.¹ Goldberger and his associates² were able to prevent, to produce and to cure the disease by varying certain constituents in a diet administered to human beings. They finally considered the lack of vitamin B₂ (G), the so-called "antidermatitis factor," as the sole cause of the disease. At the present time some investigators³ do not accept that claim, advancing the theory that a predisposing dietary lack is important in the pathogenesis of pellagra, but that a precipitating element is also necessary. I⁴ reported in a previous publication that the cutaneous lesions of persons with pellagra improved while the patients were restricted to a so-called "pellagraproducing" diet. Since this diet consisted of such diverse foods as cornmeal, pork fat, artificially colored (synthetic) maple syrup, polished rice, corn-starch pudding and . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

Teaching Fellow in Medicine, Western Reserve University.; From the H. K. Cushing Laboratory of Experimental Medicine and the Medical Service of Lakeside Hospital.

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