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WITH SPECIAL REFERENCE TO ACUTE MONOCYTIC LEUKEMIA

CLAUDE E. FORKNER, M.D.

Arch Intern Med. 1934;53(1):1-34.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Friedreich¹ in 1857 reported a case of leukemia with an acute course. Ebstein² in 1889 described the clinical picture of acute leukemia. Fraenkel³ in 1895 directed attention particularly to changes in the cells of the blood, and expressed the view that all acute leukemias were lymphogenous because of the similarity of the white blood cells of these patients to lymphocytes. Naegeli⁴ in 1900 described the myeloblast, thereby permitting, on the basis of the cytologic characteristics, the separation of two types of acute leukemia, myeloblastic or acute myelogenous and lymphoblastic or acute lymphatic. A sharp differentiation, however, was not always clear owing to difficulties in technic of staining blood smears and because of atypical cases which defied classification.

Further elucidation of the problem was forthcoming in the discovery by Reschad and Shilling-Torgau⁵ in 1913 of a third type of acute leukemia, acute monocytic leukemia. Although twenty . . . [Full Text PDF of this Article]

Author Affiliations
PEIPING, CHINA

From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, the Department of Medicine, Harvard University Medical School, and Peiping Union Medical College.

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