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XXIII. THE EFFECT OF LACK OF THE VITAMIN B COMPLEX ON THE SECRETION OF GASTRIC JUICE IN DOGS WITH GASTRIC POUCHES

GEORGE R. COWGILL, Ph.D.; ALFRED GILMAN, Ph.D.

Arch Intern Med. 1934;53(1):58-70.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A study of the effect of lack of the vitamin B complex on gastric secretion is of interest for several reasons. The first is based on analogy and is concerned with that vicious circle of pernicious anemia, gastric achylia and subacute combined sclerosis. This group of symptoms has been termed "combined system disease." The relationships of the elements of this syndrome are fascinating in their implications. It is well recognized that practically all cases of pernicious anemia are characterized by gastric achylia. In support of this view, observations of Minot and Murphy¹ and others indicating that pernicious anemia may well be classified as a deficiency disease, and the findings of Castle² that impaired gastric function plays an important rôle, may be cited. According to some investigators in this field (Hurst and Bell,³ Collier⁴ and Vanderhoof⁵), there is an almost invariable association of achylia gastrica with combined sclerosis of the spinal . . . [Full Text PDF of this Article]

Author Affiliations
NEW HAVEN, CONN.

From the Department of Physiological Chemistry, Yale University.

Footnotes
The expenses of this research were defrayed in part by a grant from the Research Fund of the Yale University School of Medicine.; Because the diets used in this study were markedly but not absolutely deficient in either vitamin B (B1 or G (B2), we use the expression "lack of vitamin B complex."; This paper is a report of some of the data contained in the dissertation presented by Alfred Gilman in partial fulfilment of the requirements for the degree of Doctor of Philosophy, Yale University, 1931.

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