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ARTHUR MARLOW, M.D.; F. H. L. TAYLOR, Ph.D.

Arch Intern Med. 1934;53(4):551-560.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Clinical studies on the production of hemoglobin following the oral administration of iron indicate the physiologic activity of this substance in hypochromic anemia. Heath and his co-workers¹ have shown that in such patients the intramuscular injection of ferric ammonium citrate is followed by a rise in hemoglobin representing approximately a quantitative reappearance of the injected iron as hemoglobin. Their observations suggest that the action of iron on the production of hemoglobin is not vaguely "catalytic" but bears a quantitative relationship to the formation of hemoglobin. The interest of investigators is, therefore, logically directed to the question of absorption of iron, since the degree of absorption of a given iron compound obviously controls the amount of iron available for the regeneration of hemoglobin.

Unless complete experiments on iron balance are performed, studies of absorption based on the elimination of iron in the feces are profitless. This is due to the . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard) of the Boston City Hospital and the Department of Medicine of the Harvard Medical School.

Footnotes
The expenses of this investigation were borne in part by a gift to Harvard University from Smith, Kline and French Laboratories, Philadelphia.

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