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THE DIFFERENCE IN CREATINE CONCENTRATION OF THE LEFT AND RIGHT VENTRICULAR CARDIAC MUSCLES
DAVID P. SEECOF, M.D.;
CHARLES R. LINEGAR, A.B.;
VICTOR C. MYERS, Ph.D., D.Sc.
Arch Intern Med. 1934;53(4):574-593.
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Although the function of creatine in muscle has not been entirely elucidated, recent studies indicate that in the form of phosphocreatine it plays a vital rôle in muscular contraction. Data on the creatine content of the heart, the body's most active muscle, should possess considerable significance. When one of us (D. P. S.) was approached with regard to collaborating on a study of the creatine content of the heart, an idea formulated during the progress of pathologic studies, namely, that the left and right ventricles were qualitatively different muscles, led to the decision to make separate determinations on the two ventricles.
The idea that the ventricles may be different originated about ten years ago, during a review of the available data on the congenital anomalies of the heart which result from defects of development of the bulbus cordis. As summarized by Keith,1 the data disclosed that the conus of
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK; CLEVELAND
From the Department of Pathology, Cleveland City Hospital, and the departments of Pathology and Biochemistry of the Western Reserve University.
Footnotes
Preliminary report read before the Experimental Medicine Section of the Cleveland Academy of Medicine, Jan. 8, 1932.
Presented in abstract at the annual meeting of the American Society of Biological Chemists, Cincinnati, April 10, 1933.
The chemical data in this paper are taken from a dissertation being submitted by Charles R. Linegar to the Graduate School of Western Reserve University in partial fulfilment of the requirements for the degree of Doctor of Philosophy.
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