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EFFECT OF EPINEPHRINE AND RELATED COMPOUNDS

M. H. NATHANSON, M.D.

Arch Intern Med. 1934;54(1):111-130.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The heart possesses several important properties. The function most familiar to the clinician is contractility which, when impaired, leads to the frequently observed slow cardiac failure. Sudden cessation of the cardiac activity, however, results from disturbance in another essential property of the heart, that of stimulus formation, termed rhythmicity or automaticity. Normally the sinus node produces the stimulus necessary for cardiac contraction, and the activity of the heart abruptly ceases if this or other rhythmic centers fail to function. Absence of an impulse-initiating mechanism is the cause of the ventricular standstill in complete heart block. The frequency with which impairment of the rhythmic function occurs in other clinical conditions is uncertain, but it probably plays a part in the sudden cardiac arrest occasionally observed on the operating table. The success with which intracardiac injection has resuscitated the asystolic heart in shock, asphyxia and various types of poisoning indicates that the . . . [Full Text PDF of this Article]

Author Affiliations
MINNEAPOLIS

From the Department of Medicine, University of Minnesota, Medical Service, Minneapolis General Hospital.

Footnotes
Read before the Section on Pharmacology and Experimental Therapeutics at the Eighty-Fourth Annual Session of the American Medical Association, Milwaukee, June 14, 1933.

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