This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

WILLIAM B. CHEW, M.D.; RICHARD P. STETSON, M.D.; GEORGE VAN S. SMITH, M.D.; O. WATKINS SMITH, Ph.D.

Arch Intern Med. 1935;55(3):431-444.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In another communication¹ observations were reported on seven patients with hemophilia in whom no demonstrable improvement in the coagulation of the blood or in the clinical state resulted from the oral and parenteral administration of various ovarian and estrogenic substances.

The failure to enhance the coagulability of the blood in hemophilia by the administration of an estrogenic substance has been noted by Blaylock,² who observed a slight increase in the coagulation time of the blood of his patient with hemophilia one week after starting daily subcutaneous injections of an "ovarian preparation obtained from the fetal fluid of cattle." Brown and Albright³ similarly observed no beneficial effect in one patient with hemophilia who was given injections of large amounts of estrogenic substance over a period of three days. More recently, Brem and Leopold⁴ have reported negative observations on the coagulation time and clinical state of a patient . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard University Medical School (Dr. Chew and Dr. Stetson), with the cooperation of the Fearing Research Laboratory of the Free Hospital for Women, Brookline, Mass. (Drs. Smith).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?