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OBSERVATIONS ON PATIENTS IN PUERTO RICO AND SUBSEQUENT EXPERIMENTS ON ANIMALS

W. B. CASTLE, M.D.; C. P. RHOADS, M.D.; H. A. LAWSON, M.D.; G. C. PAYNE, M.D.

Arch Intern Med. 1935;56(4):627-699.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1759 William Hillary¹ described a peculiar chronic type of diarrhea associated with sore tongue, pallor and emaciation which he had observed in Barbados. Then for nearly a century there appear to have been no further distinctive clinical accounts of the disorder. In 1864 Julien² enunciated the view that "Cochin-China dysentery" was a specific condition different from other forms of dysentery. Despite his arguments and the views of other first-hand observers,³ the French pathologists at home remained unconvinced. In 1880 both Manson,⁴ in Amoy, and van der Burg,⁵ in Java, described the features of the disease which Hillary had observed. Each of these observers adopted as a scientific name for the disease its popular designation in Java. Since then the individuality of "sprue" has been established and its features have been described by many authors.

Various theories of the cause of the disease have been . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON; NEW YORK; PROVIDENCE, R. I.; SAN JUAN, PUERTO RICO

From the Thorndike Memorial Laboratory, the Second and Fourth Medical Services (Harvard), Boston City Hospital; the Department of Medicine and the Department of Tropical Medicine, Harvard Medical School; the Hospital of the Rockefeller Institute for Medical Research, and the Presbyterian Hospital, San Juan.

Footnotes
The observations on patients were carried out in 1931 by members of the Commission of the Rockefeller Foundation for the Study of Anemia in Puerto Rico; those on animals were performed subsequently at the Hospital of the Rockefeller Institute for Medical Research, New York.

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