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W. M. FOWLER, M.D.; H. M. HUREVITZ, M.D.; FRED M. SMITH, M.D.

Arch Intern Med. 1935;56(6):1242-1249.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Until recent years the various xanthine derivatives were employed in the treatment of cardiac disease chiefly because of their diuretic action. The discovery that these preparations cause dilatation of the coronary arteries and the introduction of theophylline ethylenediamine in 1908¹ led to a further study of this particular pharmacologic action.

Eppinger and Hess² observed a stretching of strips of coronary arteries when they were placed in a solution of caffeine, and Gow,³ employing a similar method, noted a dilatation of arterial rings taken from the renal and splenic arteries. Hedbom⁴ was among the first to study the problem by the perfusion method and reported an increase in the coronary flow with caffeine in a concentration of 1:20,000. Loeb⁵ observed a marked increase in the rate of perfusion with theobromine but very little effect with caffeine. Heathcote,⁶ working with caffeine, theobromine and theophylline in concentrations from 1:2,000 . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Department of Internal Medicine, State University of Iowa.

Footnotes
Presented before the meeting of the American Society for Clinical Investigation, Atlantic City, N. J., April 30, 1934.

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