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FRED M. SMITH, M.D.; HERBERT W. RATHE, M.D.; W. D. PAUL, M.D.

Arch Intern Med. 1935;56(6):1250-1262.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The reduction in the coronary circulation through the gradual encroachment on the lumen due to sclerotic changes and, finally, the occlusion of vessels of varying size is primarily responsible for the cardiac disability in disease of the coronary arteries. It is thus important that treatment be directed toward the restoration and maintenance of an effective coronary circulation in this form of cardiac disease. Various remedies, particularly the xanthine derivatives, have been recommended for this purpose. In a previous communication¹ experimental data concerning the effectiveness of these preparations were reviewed, and additional observations relative to the dilating action of theophylline ethylenediamine were reported. The latter experiments in our opinion conclusively demonstrated the dilating action of this preparation on the coronary arteries of the dog.

The xanthine derivatives are well known for their diuretic action, and it is generally conceded that theophylline is the most effective of the group. Marvin² . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY; WAVERLY, IOWA; IOWA CITY

From the Department of Internal Medicine, State University of Iowa College of Medicine.

Footnotes
Presented at the Tenth Scientific Session of the American Heart Association, Cleveland, June 12, 1934.

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