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TYPE OF ANEMIA, RESPONSE TO TREATMENT, AND RELATION OF TYPE OF ANEMIA TO HISTOPATHOLOGIC CHANGES IN LIVER, SPLEEN AND BONE MARROW

M. M. WINTROBE, M.D., Ph.D.

Arch Intern Med. 1936;57(2):289-306.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Attention has been directed recently in Germany,¹ Italy² and Austria,³ as well as in this country,⁴ to the occurrence of macrocytic anemia in association with disorders of the liver. The recognition of a hematologic picture in cases of disease of the liver resembling in many respects that of pernicious anemia is not new, as a review of the literature in an earlier communication^4a indicated. Nevertheless, little significance was attributed to the association, and it has been only with the recently renewed interest in hematology that several investigators, working independently, have rediscovered this type of anemia. In several respects the various observations are essentially in agreement. The anemia associated with disorders of the liver is rarely severe.⁵ The macrocytosis affects the great majority of the red corpuscles,⁶ which show relatively little variation in shape or size.⁷ The lack of variation in the size of the corpuscles, however, does not . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Department of Medicine and the Medical Clinic, the Johns Hopkins University and Hospital.

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