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IN HYPERPARATHYROIDISM, PAGET'S DISEASE, MULTIPLE MYELOMA AND NEOPLASTIC DISEASE OF THE BONES

ALEXANDER B. GUTMAN, M.D.; T. LLOYD TYSON, M.D.; ETHEL BENEDICT GUTMAN

Arch Intern Med. 1936;57(2):379-413.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is now generally recognized that the determination of serum calcium, inorganic phosphorus and phosphatase activity, in conjunction with clinical and roentgenologic study, may provide evidence of value in the differential diagnosis of certain diseases of bone. It is becoming increasingly evident, however, that for adequate interpretation of the variations in these constituents of the blood, particularly as regards their significance with respect to the underlying physiologic mechanisms involved, more data are desirable. This study is concerned with a review and appraisal of the available relevant but scattered data relating to hyperparathyroidism, Paget's disease, multiple myeloma and neoplastic disease of the bones. Additional observations on personally studied cases are presented.

METHODS

Twenty cubic centimeters of venous blood obtained from patients while fasting was transferred to a 25 cc. pyrex centrifuge tube, allowed to clot for one-half hour and then centrifugated for from five to ten minutes at 1,000 revolutions per . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Medicine, the Columbia University College of Physicians and Surgeons and the Presbyterian Hospital.

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