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ARMAND J. QUICK, M.D., Ph.D.

Arch Intern Med. 1936;57(3):544-556.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A satisfactory test of the function of the liver should (1) detect and estimate hepatic insufficiency, (2) aid in a differential diagnosis, (3) have prognostic usefulness and (4) contribute toward a better understanding of the physiology of the liver. With these objectives, the synthesis of hippuric acid: (benzoic acid + amino-acetic acid = hippuric acid) was studied both experimentally and clinically.1 It was observed that the hourly rate of excretion of hippuric acid in normal persons following the ingestion of sodium benzoate is remarkably constant, being influenced only somewhat by the size of the subject or, more exactly, by the surface area. In certain types of disease of the liver, however, the output of hippuric acid is markedly reduced. This reduction is due primarily to the diminished capacity of the liver to synthesize amino-acetic acid and in part to damage of the enzymatic mechanism which unites benzoic acid with amino-acetic acid. In . . . [Full Text PDF of this Article]

Author Affiliations
MILWAUKEE

From the Surgical Service of Dr. Frederic W. Bancroft and the Medical Service of Dr. Charles F. Tenney, Fifth Avenue Hospital, New York.

Footnotes
Part of the paper was read before the New York Academy of Medicine, Section of Medicine, March 20, 1934.

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